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Dr. Francis Crick’s 1970 paper, Central Dogma of Molecular Biology, was on the three biopolymers (DNA, RNA, and protein) and the “transfers” between each polymer. He details both the original categorization of transfers from 1958 and then his proposed new groups with re-organized transfers.

1.) In the old categorizations of information transfer he lists transfers that “almost certainly existed”, transfers that were “rare or absent” and those that were “unlikely to occur”. What biopolymer transfers fell into these categories?

2.) What are the three classes Crick proposes to replace the old categorizations? Which types of information transfer fall into these new classes?

3.) The basis of Dr. Crick’s 1970 paper was to clarify the central dogma of molecular biology in response to the “Central Dogma Reversed” publication put forth by Dr. Howard Temin. According to Dr. Crick, the work of Dr. Temin suggests what?

4.) Name one of the aspects of the central dogma formulation that has occasionally produced misunderstandings.

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