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1. Describe the differences between deletion, insertion, substitution and


1. Describe the differences between deletion, insertion, substitution and

nonsense mutations. Provide an example of each using the following piece of DNA: TAC CAG ATA CAC TCC CCT GCT ACT. Indicate if any of the mutations are frameshift, nonsense or missense mutations.

2.  Ciprofloxacin, erythromycin, and acyclovir are used to treat microbial infections. Ciprofloxacin inhibits DNA gyrase. Erythromycin binds in front of the A site on the 50S subunit of a ribosome. Acyclovir is a guanine analog.

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a.    What steps in protein synthesis are inhibited by each drug?

b.    Which drug is more effective against bacteria? Why?

c.    Which drug is more effective against viruses? Why? Which drugs will have effects on the host’s cells? Why?

d.    Use the index to identify the disease for which acyclovir is used.

e.    Why is it more effective than erythromycin for treating this disease?

Directions: Essay responses for each question, to include an application paragraph stating how it is relevant to everyday life.

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